A study published in the open-access journal PLOS Medicine, led by Frederick Ho of the University of Glasgow, UK, found that each additional hour of prolonged, uninterrupted sedentary behavior is associated with a 9% higher risk of cancer mortality. The research, which analyzed data from 91,292 UK Biobank participants who wore activity monitors for seven days and were followed for a median of 12.38 years, defined prolonged sedentary behavior as bouts lasting at least 30 minutes with at least 90% of that period spent sedentary. In contrast, interrupted sedentary behavior—periods lasting less than 30 minutes or including more than 10% non-sedentary activity—was associated with lower risk across all examined outcomes, including overall cancer incidence and obesity- and type 2 diabetes-related cancers. The study also suggested that replacing one hour per day of prolonged sedentary behavior with light physical activity could lower the risk of cancer death by 12%. Source

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